VX-984 (Zarnestra) Smiles: CN(C)CCCN(C(=O)[C@H]1CN(CC=C)[C@@H]2CC3=CNC4=CC=CC([C@H]2C1)=C34)C(=O)NCC

Smiles: CN(C)CCCN(C(=O)[C@H]1CN(CC=C)[C@@H]2CC3=CNC4=CC=CC([C@H]2C1)=C34)C(=O)NCC

CAS Number: 1617-70-5

Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells

ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31

23-48)60-42/h17

VX-984 (Zarnestra) Smiles: CN(C)CCCN(C(=O)[C@H]1CN(CC=C)[C@@H]2CC3=CNC4=CC=CC([C@H]2C1)=C34)C(=O)NCCVX 984 is a potent DNA PK inhibitor. Product information CAS Number: 1476074 39 1 Molecular Weight: 415. 49 Formula: C23H23N7O Chemical Name: N methyl 8 [(2S) 1 {[2' methyl(4',6' H) [4,5' bipyrimidin] 6 yl]amino}propan 2 yl]quinoline 4 carboxamide Smiles: [2H]C1=NC(C)=NC([2H])=C1C1C=C(NC[C@@H](C)C2C=CC=C3C=2N=CC=C3C(=O)NC)N=CN=1 InChiKey: PEACIOGDEQRHFA KIYKJNLWSA N InChi: InChI=1S C23H23N7O c1 14(17 5 4 6 18 19(23(31)24 3)7 8 25 22(17)18)10 28 21 9